A limbal nodule is any nodular lesion at the limbus (junction of the cornea and sclera) of the eye.
The differential diagnosis for a limbal nodule can include:
Pinguecula Early Pterygium Foreign body / foreign body granuloma Phlycten, an inflamed nodule of lymphoid tissue Episcleritis Scleritis Granuloma Limbal dermoid, a kind of choristoma (NB: in other organs dermoid can refer to a teratoma) malignant melanoma naevus
A 1989 case series of 636 limbal nodules examined over a period of 40 years at the Institute of Ophthalmology in London reported that 351 nodules involved malanocytes with two-thirds being benign nevi. Seventy three lesions were squamous cell carcinomas, and 137 premalignant lesions. Ten percent of the lesions were dermoid nodules.
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