Seneca High School may refer to various high schools in the United States:
Seneca High School (Illinois), Seneca, Illinois Seneca High School MCA in Louisville, Kentucky Seneca High School (New Jersey), Tabernacle Township, New Jersey Seneca Vocational High School, Buffalo, New York, U.S., closed in 2006 Seneca High School (Pennsylvania), Erie, Pennsylvania Seneca High School (Missouri), Seneca, Missouri Seneca High School (South Carolina), Seneca, South Carolina
See also Seneca East High School, Attica, Ohio