Samuel Lewis or Sam Lewis may refer to:
Politics Samuel Lewis (educator) (1799–1854), American politician, Ohio Superintendent of Common Schools and Liberty Party candidate Samuel A. Lewis (1831–1913), American politician and philanthropist Samuel Lewis (barrister) (1843–1903), Sierra Leonean politician, lawyer, first African to be knighted Samuel S. Lewis (1874–1959), Secretary of the Pennsylvania Department of Forest and Waters in 1951–1954 Sam Lewis (trade unionist) (1901–1976), Australian trade unionist Samuel W. Lewis (1930–2014), American diplomat Samuel W. Lewis (politician), American politician Samuel Lewis Navarro (born 1957), vice president of Panama
Other Samuel Lewis, early South Australian stonemason who carved the cross on William Light's first memorial Samuel Lewis (publisher) (c. 1782–1865), editor and publisher of topographical dictionaries and maps Samuel Lewis (financier) (1837–1901), English money-lender and philanthropist Samuel E. Lewis (1840–1907), Union Army soldier, Medal of Honor recipient Sam M. Lewis (1885–1959), American singer and lyricist Samuel L. Lewis (1896–1971), American Sufi founder, Zen educator Sam Lewis (rugby union, born 1990), Welsh rugby union player Sam Lewis (rugby union, born 1998), English rugby union player Sam Lewis (game designer), American designer of board games