Mighty Mac or Mighty Macs may refer to:
Mackinac Bridge, a suspension bridge in Michigan known as the Mighty Mac Mighty Mac, nickname of the USS McKean (DD-784), a destroyer Mighty Mac, nickname of the USS McClusky (FFG-41), a frigate Mighty Mac, nickname of the USS Mackinac (AVP-13), a seaplane tender The Mighty Mac, winning horse in the 1981 Powers Gold Cup and 1984 Cathcart Challenge Cup Mighty Macs, nickname of the sports teams of Immaculata University, formerly Immaculata College The Mighty Macs, a 2009 film about the women's basketball team of what was then Immaculata College Mighty Mac, nickname of the sports teams of Bishop McNamara High School, Forestville, Maryland Mighty Macs, nickname of the sports teams of Mother McAuley Liberal Arts High School, Chicago, Illinois