Chance of a Lifetime or The Chance of a Lifetime may refer to:
Film and television The Chance of a Lifetime (1916 film), a British silent sports drama The Chance of a Lifetime (1943 film), a crime drama Chance of a Lifetime (1950 film), a British film Chance of a Lifetime (1991 film), an American film starring Betty White Chance of a Lifetime, a 1998 television film starring John Ritter and Katey Sagal Chance of a Lifetime (TV series), a 1952–1956 talent show which aired on ABC and DuMont "Chance of a Lifetime" (Knots Landing), a 1980 television episode
Other uses "Chance of a Lifetime" (Pat McGeegan song), the Irish entry in the Eurovision Song Contest 1968, performed in English by Pat McGeegan "Chance of a Lifetime", a song from the 1983 album Keep It Up by Loverboy "Chance of a Lifetime", a song from the 2003 album Mest by Mest The Chance of a Lifetime (novel), a 1907 novel by Nathaniel Gould
See also The $1,000,000 Chance of a Lifetime, a 1986–87 U.S. game show The $1,000,000 Chance of a Lifetime (Australian game show), a 1999 Australian game show It's Your Chance of a Lifetime, the 2000 U.S. version of the above Australian series Chance for a Lifetime, 2005 album by Catchpenny Chance for a Live Time, 2001 live album by Kayak