The following highways are numbered 159:
Canada Prince Edward Island Route 159 (Peter Road) Quebec Route 159
Costa Rica National Route 159
Japan Japan National Route 159
United Kingdom road B159 road
United States U.S. Route 159 Alabama State Route 159 Arkansas Highway 159 California State Route 159 (former) Colorado State Highway 159 Connecticut Route 159 Florida State Road 159 Georgia State Route 159 Illinois Route 159 Indiana State Road 159 Kentucky Route 159 Louisiana Highway 159 Maine State Route 159 Maryland Route 159 Massachusetts Route 159 Nevada State Route 159 New Jersey Route 159 New Mexico State Road 159 New York State Route 159 North Carolina Highway 159 Ohio State Route 159 Pennsylvania Route 159 (former) Tennessee State Route 159 Texas State Highway 159 Texas State Highway Spur 159 Utah State Route 159 Virginia State Route 159 Wisconsin Highway 159 Wyoming Highway 159 Territories Puerto Rico Highway 159