Santillana may refer to:
People Antonio Fernández Santillana (1876–1909), Spanish-French aviation pioneer Everardo Zapata Santillana (born 1926), Peruvian teacher and author Íñigo López de Mendoza, 1st Marquis of Santillana (1398–1458), Castilian politician and poet Leonardo Santillana (born 1998), Mexican equestrian Santillana (footballer) (born 1952), Carlos Alonso González, Spanish footballer
Places Santillana del Mar, a town in Cantabria, Spain Santillana de Campos, a hamlet of Osorno la Mayor, Palencia, Spain Santillana District, Huanta district, Peru
Other uses Grupo Santillana, a Spanish publisher owned by Penguin Random House
See also Santillán, a surname