Aydelotte is a surname and given name. Notable people with the name include:
Frank Aydelotte (1880–1956), American educator and director of the Institute for Advanced Study Myrtle Aydelotte (1917–2010), American nurse, professor and hospital administrator William O. Aydelotte (1910–1996), American historian William Aydelotte (tennis) (1903–1997), American tennis player
Middle name
Davis Aydelotte Robertson, American baseball player Henry Aydelotte Houston, American politician
Other Aydelotte, Oklahoma, a place in the US