Guillén is a surname. Notable people with the surname include:
Amparo Guillén (1953–2024), Ecuadorian actress Carlos Guillén, Venezuelan baseball player Fernando Guillén (disambiguation), multiple people Harvey Guillén (born 1990), actor Joel Guillén (born 2001), Andorran footballer Jorge Guillén, Spanish poet José Guillén (born 1976), Dominican baseball player Montserrat Guillén (born 1964), Spanish statistician and economist Nancy Guillén (born 1976), Salvadoran hammer thrower Néstor Guillén Olmos (1890–1966), President of Bolivia for 27 days Nicolás Guillén, Afro-Cuban poet Ozzie Guillén (born 1964), Venezuelan baseball player and coach Osiel Cárdenas Guillén (born 1967), Mexican drug lord Rafael Guillén known as Subcomandante Marcos, spokesman for the Zapatista Army of National Liberation Ricardo Guillén (born 1967), Spanish basketball player Tonatiuh Guillén López, Mexican academic and government official Walter Guillén Soto, Catholic bishop in Honduras
See also Murder of Vanessa Guillén Guillen