Crucifixion thorn may refer to one of the following North American desert plants:
Canotia holacantha, a shrub or small tree in the family Celastraceae native to the Mojave and Sonoran Deserts Castela emoryi, a shrub or small tree in the family Simaroubaceae native to the Mojave and Sonoran Deserts Crucifixion Thorn Natural Area, a part of the Yuha Desert named after castela emoryi Castela erecta (goatbush), a shrub or small tree in the family Simaroubaceae native to the Chihuahuan Desert Colletia cruciata Holacantha stewartii (Stewart crucifixion-thorn), a shrub or small tree in the family Simaroubaceae native to the Chihuahuan Desert Koeberlinia spinosa (allthorn), a shrub or small tree in the family Koeberliniaceae native to the Sonoran Desert