Skull Creek may refer to:
Australia Skull Creek (Northern Territory), a tributary of the Robinson River near Borroloola, Northern Territory Skull Creek (Queensland), a tributary of Saline Creek near Woorabinda, Queensland Skull Creek (Victoria), a tributary of the Mitchell River near the village of Lindenow, Victoria Skull Creek (Western Australia), a tributary of Lake Mason near the village of Sandstone in the Mid West, Western Australia
United States Skull Creek (Beaufort County, South Carolina), a historic site Skull Creek Township, Butler County, Nebraska
See also Skull Creek massacre, massacre of Karankawa people in Mexican Texas in February 1823