First strike most commonly refers to:

First strike (nuclear strategy) Preemptive war

First strike may also refer to:

Film and television First Strike (1979 film), a United States Air Force documentary First Strike (1996 film), a Hong Kong action film starring Jackie Chan Tales of Vesperia: The First Strike, a 2009 Japanese animated film "First Strike" (Stargate Atlantis), a 2007 TV episode First Strike, a 2017 short film directed by Peter Kerek

Books and comics First Strike (DC Comics), a fictional team of superheroes First Strike (IDW Publishing), a 2017 crossover event set in the Hasbro Universe Halo: First Strike, a 2003 science fiction novel by Eric Nylund, based on the video game series First Strike, a 1979 novel by Douglas Terman

Other uses First Strike (album), a 1983 album by Cobra First strike (coinage), the first coins struck from a new set of dies

See also First use (disambiguation) First Blood (disambiguation) Strike (disambiguation)