Tuiasosopo is a Samoan surname.
Tuiasosopo Mariota, a tribal leader who helped keep American Samoa from being incorporated into the United States Mariota Tiumalu Tuiasosopo (1905–1957), American Samoan songwriter
As of early 2014, its most notable bearers all belong to the same family:
Manu Tuiasosopo (born 1957), American NFL football player Peter "Navy" Tuiasosopo (1963–2025), American Samoan actor and football player, cousin of Manu Mike Tuiasosopo, American football coach, cousin of Manu and brother of Navy Marques Tuiasosopo (born 1979), American football quarterback and coach, son of Manu Leslie Tuiasosopo (born circa 1977), American volleyball coach, daughter of Manu Zach Tuiasosopo, American football player, son of Manu Matt Tuiasosopo (born 1986), American baseball player, son of Manu Lanea Tuiasosopo, American rower, daughter of Mike Ronaiah Tuiasosopo, perpetrator of the Manti Te'o girlfriend hoax, nephew of Manu