Cassuto is a surname. Notable people with the surname include:
Álvaro Cassuto (1938–2026), Portuguese composer and conductor Judah Cassuto (1808–1893), Dutch-German hazzan (cantor) of the Portuguese-Jewish community Nathan Cassuto (1909–1945), Italian ophthalmologist and rabbi Philippe Cassuto (1959–2020), French hellenist, biblical scholar and academic Sherry Cassuto (1957–2016), American rower Solica Cassuto, Greek actress, and second wife of actor Andy Griffith Thierry Cassuto (born 1959), French-born South African film and television producer Umberto Cassuto (1883–1951), Italian rabbi and biblical scholar
See also Cassutt Cassutto