Fluorenone is an organic compound with the chemical formula , and is a ketone with a fluorene moiety. It is a bright yellow, fluorescent solid.
Synthesis and reactions It is synthesised by aerobic oxidation of fluorene:
Fluorenone sustains up to four nitro groups giving 2,4,5,7-tetranitrofluorenone.
Applications
Several substituted fluorenones are biologically active as antibiotic, anticancer, antiviral, or neuromodulatory compounds.
Some substituted azafluorenones are biologically active, such as the naturally occurring antimicrobial compound onychine (1-methyl-4-azafluorenone). The compound 1,8-diazafluoren-9-one is used for fingerprint detection.
Drugs Fluorenone is used to synthesize: A drug called IPS-339 [60979-28-4]. An analog of 2-MDP.Robert B Moffett, US3325544 (1967 to Pharmacia and Upjohn Co). Paranyline (aka Renytoline, Mer 27).Allen, Robert E.; Schumann, Edward L.; Day, William C.; Van Campen, M. G. (1958). "Amidines of Certain Substituted Triphenylethylenes". Journal of the American Chemical Society 80 (3): 591–598. doi:10.1021/ja01536a020.Jr Marcus G Van Campen, Robert E Allen, Frank P Palopoli, Edward L Schumann, US2877269 (1959 to Wm S Merrell Co). Via a Beckmann rearrangement, phenanthridone [1015-89-0]. This compound is used in the synthesis of fantridone.Cookson, R. F.; James, J. W.; Rodway, R. E.; Simmonds, R. G. (1972). "Synthesis of some phenanthridone derivatives". Journal of Heterocyclic Chemistry.9 (3): 475–480. doi:10.1002/jhet.5570090303.J. W. James and R. E. Rodway, GB1135947 (1968 to Aspro Nicholas Ltd). An analog of amitriptyline, as reported by Roche: [4684-13-3].Dr Kurt Stach, et al. DE1150976 (1963 to Roche Diagnostics GmbH).Dr-Ing Kurt Stach, DE1211630 (1966 to Roche Diagnostics GmbH). CYM50769
See also Fluorenol Chlorflurenol
References
External links Material Safety Data Sheet