Sainte-Agathe or St. Agatha may refer to the following places:
Ste. Agathe, Manitoba, Canada, an unincorporated community Sainte-Agathe, Puy-de-Dôme, Thiers, France, a commune Sainte-Agathe-de-Lotbinière, Quebec, Canada Sainte-Agathe-des-Monts, Quebec, Canada St. Agatha, Maine, United States, a town St. Agatha, Ontario, a rural community in Wilmot Township, Canada Sankt Agatha, a municipality in Upper Austria
See also Agatha of Sicily, a Christian saint Sant'Agata (disambiguation)