Charles Spencer may refer to:

Nobility Charles Spencer, 3rd Earl of Sunderland (1675–1722), English statesman Charles Spencer, 3rd Duke of Marlborough (1706–1758), British soldier and politician Lord Charles Spencer (1740–1820), 2nd son of the 3rd Duke of Marlborough Charles Spencer, 6th Earl Spencer (1857–1922), British courtier and Liberal politician Charles Spencer, 9th Earl Spencer (born 1964), brother of Diana, Princess of Wales

Sports Charles Spencer (cricketer) (1903–1941), Welsh cricketer Charlie Spencer (1899–1953), England and Newcastle United footballer Charles Spencer (American football) (born 1982), American football player Tony Mamaluke (born 1977), American professional wrestler a.k.a. Charles John Spencer

Others Charles A. Spencer (1813–1881), American scientific pioneer and inventor Charles Nichols Spencer (1837–1893), Hawaiian businessman and politician Cosens Spencer (1874–1930), known posthumously as Charles Cozens Spencer, British-born Canadian film exhibitor and producer in Australia Charles S. Spencer (born 1950), American curator, researcher, and anthropologist Charles Spencer (journalist) (born 1955), British journalist and longstanding drama critic of the Daily Telegraph Charles Spencer (pianist) (born 1955), English classical pianist and music educator Charles Green Spencerr (1837–1890), pioneer aviator who founded the balloon manufacturing company C. G. Spencer & Sons Charles Spencer (Neighbours), fictional character on Australian soap Neighbours

Other uses Charles H. Spencer hulk, a 1912 steamboat that ran on the Colorado River Charles R. Spencer, a 1901 steamboat that ran on the Columbia and Willamette Rivers

See also Charles Spencer-Churchill (disambiguation)