Great Southern may refer to:
Great Southern (automobile), a car in production from 1910 to 1914 Great Southern (band), the backing band for American rock guitarist Dickey Betts Great Southern (train), a luxury train service in Australia Great Southern (Western Australia), a region in Western Australia Great Southern (wine region), in Western Australia Great Southern Group, a corporate group in Australia which collapsed in 2009 Great Southern Television, based in Auckland and Sydney TSS Great Southern (1902), a ship built in 1902 for the Great Western Railway Great Southern Bank, Australian bank
See also Great Southern Railway (disambiguation)