Zapotec () or zapoteca may refer to:
Cultures and languages Zapotec civilization, a historical indigenous pre-Columbian civilization and archaeological culture of central Mexico Zapotec languages, a group of closely related indigenous Mesoamerican languages Zapotec peoples, contemporary indigenous peoples of Mexico Zapotecan languages, a group of related Oto-Manguean languages (including Zapotec languages), of central Mesoamerica Zapotec language (Jalisco), an extinct language from Jalisco state in Mexico, unrelated (despite its name) to the group of Zapotec languages.
Other uses Zapoteca (plant), a legume genus
See also Emil Zátopek, athlete from Czechoslovakia Zátopek (film), a 2021 Czech film about him Lukáš Zátopek, Czech ice hockey player