Frank Little may refer to:
Frank Little (unionist) (1879–1917), American IWW labor leader Sir Frank Little (bishop) (1925–2008), Australian Roman Catholic archbishop Frank Little (tenor) (1939–2006), operatic tenor Frank Little, one of The Littles, fictional characters from the series of children's novels by John Peterson Frank Little (sport shooter) (1936–1993), American Olympic shooter
See also Francis Little (disambiguation)