George Scha(e)f(f)er may refer to:
George J. Schaefer (1888–1981), American film producer and studio executive George Schaefer (finance), American banking executive George Schaefer (director) (1920–1997), American television and theatre director and president of the Directors Guild of America George Schaefer (businessman) (1928–2013), American businessman, CEO of Caterpillar Inc. George Schaefer (bishop) (born 1950), bishop of the Russian Orthodox Church Outside of Russia George Schaeffer, American football player George C. Schaeffer (1814–1873), American engineer, chemist, and librarian George E. Schafer (1922–2015), United States Air Force surgeon general Georg Schäfer (industrialist) (1896–1975), German industrialist and art collector Georg Schäfer (artist) (1926–1991), German-American painter Georg Anton Schäffer (1779–1836), German physician George Schaefer (baseball) (born 1989), American baseball coach and pitcher