N53 may refer to:
Roads N53 road (Ireland), a road in the Republic of Ireland split by the border with Northern Ireland Nebraska Highway 53, in the United States Santiago–Tuguegarao Bypass Road, in the Philippines
Other uses N53 (Long Island bus) BMW N53, an automobile engine , a submarine of the Royal Navy , a minelayer of the Royal Norwegian Navy London Buses route N53 Stroudsburg–Pocono Airport, in Monroe County, Pennsylvania, United States