Oosterhuis is a Dutch surname meaning "eastern house".Oosterhuis at the Database of Surnames in The Netherlands Notable people with the surname include:

Allard Oosterhuis (1902–1967), Dutch resistance hero during World War II Anuska Oosterhuis (born 1978), Dutch media artist Huub Oosterhuis (1933–2023), Dutch theologian, poet and former Catholic priest; father of Tjeerd and Trijntje Jon Oosterhuis (born 1977), Canadian football fullback Kas Oosterhuis (born 1951), Dutch architect Peter Oosterhuis (1948–2024), English golfer Tjeerd Oosterhuis (born 1971), Dutch musician and producer, brother of Trijntje Trijntje Oosterhuis (born 1973), Dutch singer and songwriter, sister of Tjeerd

See also Oostershuis, a building in Antwerp and a headquarters of the Hanseatic League, erected about 1560 and destroyed by fire in 1893.

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