This is a list of roads that have quadrant route numbers or state route numbers assigned by PennDOT, the Pennsylvania Department of Transportation.

__NOTOC__ Capital Beltway (Harrisburg) Derry Street Interstate 76 Interstate 78 Interstate 81 Interstate 83 Interstate 283 Paxton Street Pennsylvania Route 39 Pennsylvania Route 230 Pennsylvania Route 441 Pennsylvania Route 501 Pennsylvania Route 581 State Route 3015 (Dauphin County, Pennsylvania) State Route 3017 (Dauphin County, Pennsylvania) State Route 3020 (Dauphin County, Pennsylvania) US 11 US 15 US 22 US 30 US 322 US 422