George Woodruff may refer to:
George Catlin Woodruff (1805–1885), American politician, U.S. Representative from Connecticut George Cecil Woodruff (1888–1968), American businessman and football coach George Washington Woodruff (1864–1934), American football coach acting Secretary of the Interior Bob Woodruff (American football) (George Robert Woodruff, 1916–2001), American football coach George W. Woodruff (1895–1987), American businessman and philanthropist