Santa Susana may refer to:
Susanna (disciple), disciple of Jesus according to the gospel of Luke; Susanna of Rome, martyred in 295.
Santa Susana or Santa Susanna may also refer to several places: Santa Susana, California, a census-designated place in Ventura County Santa Susana Mountains in southern California. Santa Susana Mountains, a mountain range northwest of Los Angeles Santa Susana Pass, running through the Santa Susana Mountains Santa Susana Field Laboratory, near Los Angeles, a test facility for rockets and (formerly) nuclear reactors Santa Susanna, Rome, a church on the Quirinal in Rome Santa Susanna, Spain, a small town on the Costa del Maresme of Spain