SMEI may refer to:

Severe myoclonic epilepsy of infancy (SMEI), also known as Dravet's syndrome, a form of generalized epilepsy with febrile seizures plus. Borderline SMEI (SMEB), a related condition to the above. The Solar Mass Ejection Imager aboard the Coriolis satellite. See also Smei, a village near Costeşti, Romania Sales & Marketing Executives International