HST may refer to:
People Harry S. Truman (1884–1972), 33rd president of the US Hunter S. Thompson (1937–2005), American journalist and author
Science and technology Hubble Space Telescope Harvard–MIT Program in Health Sciences and Technology History of science and technology High-speed telegraphy, a radiosport High-Speed Transfer, a USRobotics modem protocol Highstand systems tract, in the sequence stratigraphy branch of geology
Transportation and military Hastings railway station, Melbourne (Station code), Australia Helicopter support team, in the US Marine Corps Helsinki City Transport (Swedish: ) Heritage Shunters Trust, an English rail preservation society High-speed train, a type of rail transport InterCity 125 or High Speed Train, UK High Street (Glasgow) railway station (station code), Scotland High Sierra Trail, in California, US Homestead Air Reserve Base (IATA code), Florida, US USS Harry S. Truman (nickname: HST), an aircraft carrier of the US Navy High-speed transport, a type of amphibious assault ship
Other uses Harmonized sales tax, in Canada Hawaii–Aleutian Standard Time (UTC−10) Hegemonic stability theory, in international relations Holden Street Theatres, Adelaide, Australia Hospital Santo Tomás, in Panama City, Panama Host Hotels & Resorts (stock ticker $HST), American REIT