Upthegrove is a surname. Notable people with the surname include:
Dave Upthegrove, American politician Dewitt Upthegrove, American businessman and politician Laura Upthegrove, 20th-century American outlaw, bank robber, bootlegger and pirate William Hendry Upthegrove, American army captain
See also Op den Graeff family Upthegrove Beach, Florida, an unincorporated community in Okeechobee County, Florida, United States