R-110, R110, R.110, R 110 or variant may refer to:
Road 110 Route 110 (highway 110) R110 road (Ireland) Freon R-110 (hexachloroethane), see List of refrigerants R110, designation for the prototype New Technology Train on the New York City Subway, specifically: R110A (New York City Subway car) R110B (New York City Subway car) R110, the fictional robot, see TimeSplitters
See also Škoda 110 R