Crescenzi () is an Italian surname derived from the given name Crescenzo or Crescenzio. Notable people with the name include:
the following members of the Roman aristocratic family of Crescentii: Alessandro Crescenzi (cardinal) (1607–1688), Italian Roman Catholic cardinal Giovanni Battista Crescenzi (1577–1635), Italian painter and architect Marcello Crescenzi (1500–1552), Italian Roman Catholic cardinal Marcello Crescenzi (bishop of Assisi) (died 1630), Italian Roman Catholic prelate Ottaviano dei Crescenzi Ottaviani (1095–1164), Ghibelline antipope as Victor IV Pier Paolo Crescenzi (1572–1645), Italian Roman Catholic cardinal Alessandro Crescenzi (born 1991), Italian footballer Alexander Crescenzi (), Italian mathematician, translator and scholar Andrew Crescenzi (born 1992), Canadian ice hockey player Luca Crescenzi (born 1992), Italian footballer Pierluigi Crescenzi, Italian computer scientist and academic Pietro de' Crescenzi or Pier Crescenzi (1230/35–), Italian jurist and writer on agriculture Ugo Crescenzi (1930–2017), Italian politician