Sântioana may refer to several places in Romania:
Sântioana, a village in Mărișelu Commune, Bistrița-Năsăud County Sântioana, a village in Țaga Commune, Cluj County Sântioana, a village in Viișoara Commune, Mureș County Sântioana de Mureș, a village in Pănet Commune, Mureș County Sântioana (river), a tributary of the Târnava Mică in Mureș County