HPU may refer to:

Universities Hawaii Pacific University, in Honolulu, Hawaii, US High Point University, in High Point, North Carolina, US Himachal Pradesh University, in Shimla, Himachal Pradesh, India Howard Payne University, in Brownwood, Texas, US Henan Polytechnic University, in Jiaozuo, Henan, China

Computing Hogel processing unit, a parallel computation device for a holographic light-field display Holographic processing unit, a custom coprocessor by Microsoft

Other uses Hapur Junction railway station (station code), in India Team Hitec Products, a professional cycling team Home plate umpire in baseball

See also