Osilo () is a town and comune (municipality) in the Metropolitan City of Sassari in the autonomous island region of Sardinia in Italy, located about north of Cagliari and about east of Sassari. It has 2,732 inhabitants. It is part of the Anglona traditional region.

The municipality of Osilo contains the frazioni (subdivisions, mainly villages and hamlets) Santa Vittoria and San Lorenzo.

Osilo borders the municipalities of Cargeghe, Codrongianos, Muros, Nulvi, Ploaghe, Sassari, Sennori, and Tergu.

Demographics As of 2026, the population is 2,732, of which 49.0% are males, and 51.0% are females. Minors make up 10.0% of the population, and seniors make up 30.3%.

Immigration As of 2025, immigrants make up 2.7% of the population. The 5 largest foreign countries of birth are Romania, Germany, Tunisia, Argentina, and Ukraine.

Sights The sights include a castle and several churches.

Economy The economy is mostly based on agriculture and animal husbandry, especially of sheep, which include about 250 dairy companies. It is the production center of the Osilo pecorino cheese.

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