HSR may refer to: Arts and media Historical Social Research, a quarterly journal Honkai: Star Rail, a 2023 gacha video game
Biology and medicine Health services research Heat shock response, via HSPA1A gene Homogeneously staining region
Computing Hidden surface removal Hierarchical state routing High-availability Seamless Redundancy
Places
Haliburton Scout Reserve, a Scouts Canada camp Hochschule für Technik Rapperswil, a university in St. Gallen, Switzerland HSR Layout, a suburb of Bangalore, India
Transport Hamilton Street Railway, a transit agency in Ontario, Canada High-speed rail Higher-speed rail High-Speed Research Program, a 1990–1999 NASA supersonic jet program Hisar Junction railway station, in Haryana, India Historic Sportscar Racing, an American historic motorsport series Holyoke Street Railway, a former transit system in western Massachusetts Hot Springs Municipal Airport, South Dakota, US Mitsubishi HSR, a concept car
Other uses Hart–Scott–Rodino Antitrust Improvements Act, a 1976 US federal law