Jeffs is a surname that may refer to:
A.S. Jeffs (1871–1905), American football coach Brent W. Jeffs, American author, advocate and member of the Fundamentalist Church of Jesus Christ of Latter-Day Saints Charles Jeffs (1895–1974), British World War I flying ace Christine Jeffs (born 1963), New Zealand director, editor and screenwriter A. Dean Jeffs (1928–2018), American politician Heleman Jeffs (born 1993), American high ranking member of the Fundamentalist Church of Jesus Christ of Latter-Day Saints Ian Jeffs (born 1982), English footballer Lance Jeffs, Australian pharmacist Lyle Jeffs, American bishop in the Fundamentalist Church of Jesus Christ of Latter-Day Saints Nephi Jeffs, American member of the Fundamentalist Church of Jesus Christ of Latter-Day Saints Rachel Jeffs, American former member of the Fundamentalist Church of Jesus Christ of Latter-Day Saints Rulon Jeffs (1909–2002), American former President of the Fundamentalist Church of Jesus Christ of Latter-Day Saints Seth Jeffs, American official in the Fundamentalist Church of Jesus Christ of Latter-Day Saints Tim Jeffs (born 1965), American musician Toni Jeffs (born 1968), New Zealand freestyle swimmer Warren Jeffs (born 1955), American convicted sex offender and former President of the Fundamentalist Church of Jesus Christ of Latter-Day Saints