Karnes City Independent School District is a public school district based in Karnes City, Texas (USA).
Located in Karnes County, a small portion of the district extends into Atascosa County.
In 2009, the school district was rated "recognized" by the Texas Education Agency.
Schools Karnes City High (Grades 9–12) Karnes City Junior High (Grades 6–8) Roger E. Sides Elementary (Grades PK-5)
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