Tlaxcala is a Mexican state.

Tlaxcala may also refer to:

Tlaxcala (city), the capital city of the Mexican state of Tlaxcala and seat of the municipality Tlaxcala Municipality Tlaxcala Territory 1824–1857 Tlaxcala (Nahua state), the pre-Columbian city and state

See also Tlaxcaltec, a Nahua people who live in the Mexican state of Tlaxcala San Esteban de Nueva Tlaxcala, a Tlaxcalan municipality in what is now the Mexican state of Coahuila