Serena is an unincorporated community and census-designated place in LaSalle County, Illinois, United States. As of the 2020 census, Serena had a population of 129. Serena has a post office with ZIP code 60549.ZIP Code Lookup Serena was the residence of Peg McDonnell Breslin, the first woman elected to the Illinois Appellate Court outside Cook County.Illinois Blue Book 1977-1979 pages 58 and 143 Geography Serena is located at . According to the 2021 census gazetteer files, Serena has a total area of , all land.
Demographics Serena first appeared as a census designated place in the 2020 U.S. census.
As of the 2020 census there were 129 people, 4 households, and 4 families residing in the CDP. The population density was . There were 59 housing units at an average density of . The racial makeup of the CDP was 89.92% White, 2.33% African American, 0.78% Native American, 2.33% Asian, and 4.65% from two or more races. Hispanic or Latino of any race were 6.20% of the population.
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