L&S may refer to: L&S, commonly known as Leedy & Strupe, a company formed after the purchase of the Leedy Manufacturing Company Laverne & Shirley, an American television situation comedy Lilo & Stitch (franchise), a Disney franchise Lilo & Stitch, a 2002 animated film and the first film in the franchise Lilo & Stitch (2025 film), a live-action and CGI reimagining of the 2002 film Lilo Pelekai and Stitch (Lilo & Stitch), the title character duo of the franchise the Lehigh and Susquehanna Railroad, a defunct railroad in Pennsylvania A Latin Dictionary, often referred to as "Lewis and Short" Lucas & Steve, a Dutch EDM duo