Upo or UPO may refer to:
Organizations United Partisan Organization, Jewish resistance organization in the Vilna Ghetto Universidad Pablo de Olavide, a university in Seville, Spain United Planning Organization, Washington's community action agency for Capital Area Food Bank
Musical groups U.P.O., a post-grunge band from Los Angeles, California Ural Philharmonic Orchestra, from Yekaterinburg, Russia Urbana Pops Orchestra, Urbana, Illinois, United States
Other uses Upo, Shita people, Ethiopia Upo Wetland, Changnyeong County, South Korea Unpentoctium, an unsynthesized chemical element Unit Post Orderlies, see history of the British Army postal service ÇOMÜ Ulupınar Observatory, Turkey Upo, the Cebuano name for calabash