AD 454 was a year of the Julian calendar.
454 may also refer to: 454 BC, a year of the pre-Julian Roman calendar 454 Life Sciences, an American biotech company .454 Casull, a handgun cartridge 454, a model of the Chevrolet big-block engine 454 Mathesis, a main-belt asteroid 454 (rapper), American rapper and record producer (born 1996)
See also 454th (disambiguation)