UPB may refer to:

Union of Poles in Belarus Universal Powerline Bus, a proprietary home automation protocol (2003) Universidad Pontificia Bolivariana University of Paderborn University of Pittsburgh at Bradford University of the Philippines Baguio University POLITEHNICA of Bucharest

Upb may refer to: Unpentbium, an unsynthesized chemical element with atomic number 152 and symbol Upb

See also UBP (disambiguation)