Santangelo is an Italian surname and may refer to:
Santangelo novels, a series of novels by Jackie Collins Santangelo family, a fictional family from the novels
People with the surname Santangelo F. P. Santangelo (born 1967), American baseball player Mara Santangelo (born 1981), Italian tennis player George Santangelo, American genomicist Matt Santangelo (born 1977), American–Italian basketball player Alfred E. Santangelo (born 1912), American lawyer and politician Enrico Santangelo (born 1963), Italian author and art historian
Santángelo Duke of Santángelo, a hereditary title in the Peerage of Spain Jorge Cocco Santángelo (born 1936), Argentine painter and professor of art
See also Elektra v. Santangelo, a 2005 court case San Angelo, Texas Sant'Angelo (disambiguation)