Denio can refer to:
People Amy Denio (born 1961), soundtrack composer and songwriter Elizabeth Denio (1842–1922), American teacher, first woman to teach at the University of Rochester Hiram Denio (1799–1871), American lawyer and politician, Chief Judge of the New York Court of Appeals Dênio Martins (born 1977), Brazilian footballer Denio Canton (1919-2005), Cuban professional baseball pitcher
See also Samfundet De Nio, Swedish literary society