Route 405 or Highway 405 may refer to:
Canada Manitoba Provincial Road 405 Newfoundland and Labrador Route 405 Ontario Highway 405
Costa Rica National Route 405
Japan Japan National Route 405
United Kingdom A405 road
United States Interstate 405 Interstate 405 (California), a bypass of Los Angeles, California Interstate 405 (Oregon), a bypass of Portland, Oregon Interstate 405 (Washington), a bypass of Seattle, Washington Florida: Florida State Road 405 County Road 405 (Brevard County, Florida) Georgia State Route 405 (unsigned designation for Interstate 95) Maryland Route 405 New York: New York State Route 405 (former) County Route 405 (Albany County, New York) County Route 405 (Erie County, New York) Pennsylvania Route 405 Puerto Rico Highway 405 Virginia State Route 405