Xenopol is a Romanian surname. It is the surname of the notable Xenopol family from Romania, a family of Greek and Jewish origins. It may refer to:
Adela Xenopol (1861–1939), Romanian writer and feminist, sister of Alexandru and Nicolae Alexandru Dimitrie Xenopol (1847–1920), Romanian scholar, essayist, historic, member of the Romanian Academy, brother of the second Margareta Xenopol (1892-1979), composer and pianist, daughter of Alexandru Nicolae Xenopol (1858–1917), Romanian politician and diplomat, brother of the first
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