Chernoff may be either a Jewish surname, meaning "descendant of Charna" or a German-language transliteration of the Russian surname Chernov. Notable people with the surname include:
Herman Chernoff (1923–2026), American applied mathematician, statistician and physicist Maxine Chernoff (born 1952), American novelist, writer, poet, academic and literary magazine editor Mike Chernoff (disambiguation), multiple people Paul Chernoff (1942–2017), American mathematician
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