Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene.
Clinical significance A deficiency in Arylsulfatase A is associated with metachromatic leukodystrophy, an autosomal recessive disease. Multiple sulfatase deficiency (MSD) is also associated with the ARSA gene.
Biochemistry
Enzyme regulation Arylsulfatase A is inhibited by phosphate, which forms a covalent bond with the active site 3-oxoalanine.
References
Further reading
External links GeneReviews/NCBI/NIH/UW entry on Arylsulfatase A Deficiency - Metachromatic Leukodystrophy OMIM entries on ARSA Deficiency