James Holden may refer to:
Engineers James Holden (mechanical engineer) (fl. 1802), British mechanical engineer, see William Cockerill James Holden (locomotive engineer) (1837–1925), British locomotive engineer
Others James Holden (actor) (1920–2005), American actor James Holden (footballer) (born 2001), an English professional football goalkeeper James Holden (producer) (born 1979), electronic music artist and producer James Bismark Holden (1876–1956), politician from Alberta, Canada James Stuart Holden (1914–1996), U.S. federal judge James Alexander Holden (1835–1887), businessman in South Australia James Holden, character in the novel series The Expanse and its television adaptation James T. Holden (born 1905), 800 m runner-up at the 1925 USA Outdoor Track and Field Championships